ea0041oc10.2 | Reproduction & Endocrine Disruption | ECE2016
Riccetti Laura
, Akli Ayoub Mohammed
, Klett Daniele
, Yvinec Romain
, Gallay Nathalie
, Combarnous Yves
, Casarini Livio
, Simoni Manuela
, Reiter Eric
Human luteinizing hormone (LH) and human choriogonadotropin (hCG) were considered biologically equivalent for decades due to structural similarities and binding to the same receptor (LHCGR). However, LHCGR triggers differential, LH- and hCG-specific, cAMP production, steroidogenesis, ERK and AKT activation and gene expression in granulosa cells. Besides the Gs/cAMP/PKA pathway, hCG and LH bioactivity on β-arrestin- and Gq/PLC-dependent pathways are yet to be determined. W...